Blood markers could help predict outcome of infant heart surgery

New research suggests it may be possible to predict an infant’s progress following surgery for congenital heart disease by analysing a number of important small molecules in the blood.


“The presence of certain molecules in a child’s blood following heart surgery can help predict how well a child will recover in the crucial hours and days immediately following surgery.”    – Nazima Pathan


The study, published in the journal Critical Care Medicine and carried out at Royal Brompton Hospital, followed children undergoing surgery for congenital heart disease, and found that by analysing metabolites in the blood – molecules created as a result of metabolism – it was possible to predict a child’s clinical outcome.

Congenital heart disease is relatively common, affecting between 4 and 14 babies in every 1,000 live births. Around one third of affected children require surgery during early childhood. However, surgery itself can cause complications, affecting inflammation (how the body responds to in jury and infection), the endocrine system (which regulates metabolism, growth and development, tissue function, sleep, and mood, among other things) and metabolism itself. Congenital heart disease is known to affect children’s growth, surgery and chronic disease can affect their metabolism and ability to absorb essential nutrients.

In a study funded by the British Heart Foundation, a team of UK researchers followed 28 children (with a median age of 6.6 months) who were undergoing surgery for congenital heart disease. The children were part of a wider trial looking at management of blood sugar in 1,300 critically ill children and hence 15 of the children had their blood sugar levels tightly controlled using insulin, whilst the remaining 13 underwent the standard blood sugar control treatment. The researchers took blood samples from before surgery through to 48 hours afterwards, and analysed the various molecules present using nuclear magnetic resonance (NMR).

The researchers found a link between certain metabolites found in the blood and a child’s clinical outcome. The greater the presence of ketone bodies – chemicals produced when the body does not have enough insulin in the blood and must break down fat instead of the sugar for energy – correlated with better outcomes. However, the presence of other metabolites such as citrate, lactate and alanine correlated with poorer outcomes. This supports previous research in adults with critical illness.

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